Novel Peptide Inhibitors of Angiotensin-converting Enzyme 2
نویسندگان
چکیده
منابع مشابه
Angiotensin converting enzyme inhibitors.
The purpose of this brief review is to separate the characteristic properties and side effects attributable to the pharmacology of the whole class of angiotensin converting enzyme (ACE) inhibitors from those attributable to the chemical structure and kinetics of each particular ACE inhibitor. The former would be predictable and probably similar for all agents and, therefore, would be expected t...
متن کاملAngiotensin-converting enzyme inhibitors.
ACE inhibitors have achieved widespread usage in the treatment of cardiovascular and renal disease. ACE inhibitors alter the balance between the vasoconstrictive, salt-retentive, and hypertrophic properties of angiotensin II (Ang II) and the vasodilatory and natriuretic properties of bradykinin and alter the metabolism of a number of other vasoactive substances. ACE inhibitors differ in the che...
متن کاملBinding of Peptide Substrates and Inhibitors of Angiotensin - converting Enzyme
Among three biologically active substrates of angiotensin-converting enzyme, enzyme-binding affinities increase and chloride ion rate enhancements decrease in the following order: angiotensin I (Asp-Arg-Val-TyrIle-His-Pro-Phe-His-Leu), bradykinin (Arg-Pro-ProGly-Phe-Ser-Pro-Phe-Arg), bradykinin-potentiating peptide 5, (<Glu-Lys-Trp-Ala-Pro). Qualitatively simil a r properties are observed among...
متن کاملAntioxidant activity of peptide-based angiotensin converting enzyme inhibitors.
Angiotensin converting enzyme (ACE) inhibitors are important for the treatment of hypertension as they can decrease the formation of vasopressor hormone angiotensin II (Ang II) and elevate the levels of vasodilating hormone bradykinin. It is observed that bradykinin contains a Ser-Pro-Phe motif near the site of hydrolysis. The selenium analogues of captopril represent a novel class of ACE inhib...
متن کاملMilk protein-derived peptide inhibitors of angiotensin-I-converting enzyme.
Numerous casein and whey protein-derived angiotensin-I-converting enzyme (ACE) inhibitory peptides/hydrolysates have been identified. Clinical trials in hypertensive animals and humans show that these peptides/hydrolysates can bring about a significant reduction in hypertension. These peptides/hydrolysates may be classified as functional food ingredients and nutraceuticals due to their ability ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2003
ISSN: 0021-9258
DOI: 10.1074/jbc.m212934200